Aim 1: The aim of this research is to examine the results of periacetabular and femoroacetabular osteoplasty procedures in patients with symptomatic non-arthritic hip disease using clinical and radiographic evaluation.
Corticosteroid injections are commonly used for the symptomatic treatment of knee osteoarthritis. Common practice is to inject the joint with a combination of corticosteroid and local anesthetic, with the rationale of providing longer duration pain relief with the corticosteroid and immediate, though short duration relief with the anesthetic.
However, multiple in vitro and animal studies have shown that local anesthetic may be harmful to chondrocytes. Despite this data, use of intra-articular anesthetic remains widespread. Many clinicians believe incorporating the anesthetic is important because it can provide immediate pain relief and facilitate patient confidence in the treatment program. However, there is The purpose of this study is to assess and compare regenerative injection therapies such as bone marrow aspiration and concentration BMAC and platelet rich plasma PRP for osteoarthritis.
The purpose of this study is to determine if a treatment based on the combination of platelet rich plasma and HA obtained with the A-CP HA Kit is statistically superior to a saline placebo or HA alone in terms of Improvement of OA-related symptoms between baseline D0 and Month 6, and reduction of pain at walking between baseline D0 and Month 6.
The purpose of this study is to evaluate the safety and feasibility of concentrated bone marrow aspirate administration after Comprehensive Arthroscopic Management CAM surgical procedure, and to determine pain relief, disease progression and range of motion in patients with osteoarthritis of the shoulder. The purpose of this study is to compare the postoperative pain levels both in the hospital setting as well as daily for two weeks following discharge between patients in the opioid treatment group and those in the non-opioid treatment group.
This study aims to compare postoperative pain levels between three 3 treatment groups, using the Numerical Rating Scale NRS. The purpose of the study is to identify a possibly novel mutation in an individual with early onset osteoarthritis.
The purpose of this study is to learn the effects of synovial fluid, a clear thick joint lubricant, on joint cartilage tissue and the development of osteoarthritis.
The primary aim of the study is to see if a single wrist injection intra-articular of dexamethasone at the time of treatment will reduce the incidence of early-onset of post traumatic osteoarthritis. Preliminary report of four patients.
Cell death in osteoarthritis. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99 , — Pretreatment with interferon-gamma enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis. Stem Cells 29 , — Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis. Osteogenesis in transplants of bone marrow cells.
Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation. Regulatory T-cell generation and kidney allograft tolerance induced by mesenchymal stem cells associated with indoleamine 2,3-dioxygenase expression. Transplantation 90 , — The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. Tissue Res. The secreted protein thrombospondin 2 is an autocrine inhibitor of marrow stromal cell proliferation. Bone Miner.
Activation of matrix metalloproteinases 2, 9, and 13 by activated protein C in human osteoarthritic cartilage chondrocytes. Arthritis Rheumatol. Autocrine action of thrombospondin-2 determines the chondrogenic differentiation potential and suppresses hypertrophic maturation of human umbilical cord blood-derived mesenchymal stem cells.
Stem Cells 33 , — Thrombospondin-2 secreted by human umbilical cord blood-derived mesenchymal stem cells promotes chondrogenic differentiation. Stem Cells 31 , — Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial.
Stem Cells 32 , — Modulation of macrophage efferocytosis in inflammation. Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 24 , — Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide.
Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis. Arthritis Rheum. Stem Cell Res. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet , — Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension.
Circulation , — Effects of doxycycline on mesenchymal stem cell chondrogenesis and cartilage repair. Proteomic analysis of tumor necrosis factor-alpha-induced secretome of human adipose tissue-derived mesenchymal stem cells.
Proteome Res. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG Cell Stem Cell 5 , 54— Activated mesenchymal stem cells increase wound tensile strength in aged mouse model via macrophages. Paracrine action mediate the antifibrotic effect of transplanted mesenchymal stem cells in a rat model of global heart failure. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis.
Cell Cycle 17 , — The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis. Adipose stromal cells mediated switching of the pro-inflammatory profile of M1-like macrophages is facilitated by PGE2: in vitro evaluation. A regulatory cross-talk between Vgamma9Vdelta2 T lymphocytes and mesenchymal stem cells. Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis.
Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. IDO expression by dendritic cells: tolerance and tryptophan catabolism.
Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-alpha. Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling.
Stem cell therapy in a caprine model of osteoarthritis. Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response. Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury.
Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets.
Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?
Arthritis Res. CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells.
Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase i dose-escalation trial. Stem Cells Transl. Conditioned media from adipose-tissue-derived mesenchymal stem cells downregulate degradative mediators induced by interleukin-1beta in osteoarthritic chondrocytes.
Mediators Inflamm. Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells repair critical-sized bone defects through enhanced angiogenesis and osteogenesis in osteoporotic rats. Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner.
Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Save this study. Warning You have reached the maximum number of saved studies Listing a study does not mean it has been evaluated by the U. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating.
Read our disclaimer for details. Last Update Posted : July 8, See Contacts and Locations. Study Description. MedlinePlus related topics: Osteoarthritis. FDA Resources. Arms and Interventions. Autologous adipose-derived stem cells Culture expanded mesenchymal stem cells isolated from a patient's own abdominal fat tissue.
Publications automatically indexed to this study by ClinicalTrials. Arthritis Res Ther. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Osteoarthritis of Knee. Phase 2. Study Type :. Interventional Clinical Trial. Actual Enrollment :. Study Start Date :. Actual Primary Completion Date :. Actual Study Completion Date :.
0コメント